"If you suspect you’re rebounding, talk to your doctor," says Dr. If you have been feeling much better for several days and haven’t had a fever for 48 hours or more, a reemergence of symptoms is probably a rebound. If you are recovering from COVID-19, pay attention to how things are progressing. It’s not always easy to tell the difference between a true rebound and simply a very slow improvement in symptoms. Gandhi, who stresses that there’s not enough evidence to be sure and that more research is needed before doctors have answers about the causes of rebound COVID-19. "We know that a second course of treatment, or a longer duration, is sometimes necessary for other illnesses," says Dr. That theory is based in part on what scientists know about other viruses. A second round of Paxlovid, or taking it for more than five days, may resolve the issue. Those remaining traces may cause viral levels to climb back up days after treatment stops. The treatment consists of three different drugs, and if the patient doesn’t get a high enough dose of nirmatrelvir-the part of Paxlovid that targets COVID-19 enzymes-pockets of SARS-CoV-2 may survive. Gandhi.Īnother explanation is that for some patients, Paxlovid may simply need to be taken for longer than five days. "One theory is that the virus stopped multiplying when the patient took Paxlovid, but briefly surged after the treatment was finished, leading to a reappearance of symptoms," says Dr. Researchers also think it’s unlikely that SARS-CoV-2 has become resistant to the drug. It’s not because the treated patients have a weak immune response or that Paxlovid didn’t work, Dr.
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